Urinary phthalate and DINCH metabolite concentrations and gradations of maternal glucose intolerance.

ABSTRACT:

Background

Studies suggest a link between pregnancy phthalate exposures and gestational diabetes mellitus (GDM). Few studies have evaluated associations between phthalate biomarkers (individual or mixtures) with gradations of maternal glucose intolerance.

Methods

In a subset of 606 women participating in LIFECODES pregnancy cohort, a combination of 50-gram 1-h non-fasting glucose load test (GLT) and 100-gram 3-h fasting oral glucose tolerance test was used to determine pregnancy glycemic status (median: 27 weeks gestation): normoglycemia (n = 136), impaired glucose tolerance (IGT) (n = 296), and GDM (n = 174). Nineteen metabolites of phthalates and their replacements were measured during each trimester. We used multivariable logistic regression models to evaluate association

SUBMITTER: James-Todd T 

PROVIDER: S-EPMC10723583 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature