Dataset Information

Serological evidence of virus infection in Eidolon helvum fruit bats: implications for bushmeat consumption in Nigeria.

ABSTRACT:

Introduction

The Eidolon helvum fruit bat is one of the most widely distributed fruit bats in Africa and known to be a reservoir for several pathogenic viruses that can cause disease in animals and humans. To assess the risk of zoonotic spillover, we conducted a serological survey of 304 serum samples from E. helvum bats that were captured for human consumption in Makurdi, Nigeria.

Methods

Using pseudotyped viruses, we screened 304 serum samples for neutralizing antibodies against viruses from the Coronaviridae, Filoviridae, Orthomyxoviridae and Paramyxoviridae families.

Results

We report the presence of neutralizing antibodies against henipavirus lineage GH-M74a virus (odds ratio 6.23; p < 0.001), Nipah virus (odds ratio 4.04; p = 0.00031), bat influenza H17N10 virus (odds ratio 7.25; p < 0.001) and no significant association with Ebola virus (odds ratio 0.56; p = 0.375) in this bat cohort.

Conclusion

The data suggest a potential risk of zoonotic spillover including the possible circulation of highly pathogenic viruses in E. helvum populations. These findings highlight the importance of maintaining sero-surveillance of E. helvum, and the necessity for further, more comprehensive investigations to monitor changes in virus prevalence, distribution over time, and across different geographic locations.

SUBMITTER: Cantoni D

PROVIDER: S-EPMC10723585 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Serological evidence of virus infection in <i>Eidolon helvum</i> fruit bats: implications for bushmeat consumption in Nigeria.

Cantoni Diego D Mayora-Neto Martin M Derveni Mariliza M da Costa Kelly K Del Rosario Joanne J Ameh Veronica O VO Sabeta Claude T CT Auld Bethany B Hamlet Arran A Jones Ian M IM Wright Edward E Scott Simon D SD Giotis Efstathios S ES Banyard Ashley C AC Temperton Nigel N

Frontiers in public health 20231127

<h4>Introduction</h4>The <i>Eidolon helvum</i> fruit bat is one of the most widely distributed fruit bats in Africa and known to be a reservoir for several pathogenic viruses that can cause disease in animals and humans. To assess the risk of zoonotic spillover, we conducted a serological survey of 304 serum samples from <i>E. helvum</i> bats that were captured for human consumption in Makurdi, Nigeria.<h4>Methods</h4>Using pseudotyped viruses, we screened 304 serum samples for neutralizing anti ...[more]

PMID: 38106901

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