Synthesis and Characterization of Fluorescence Active G₄-Quartet and Direct Evaluation of Self-Assembly Impact on Emission.

ABSTRACT: Fluorescence (FL) active 8-aryl guanosine derivatives were prepared and applied for cation mediated self-assembly to form the H-bonded G₈-quadruplexes. The p-cyano (p-CN) and 8-anthracene (8-An) substituted guanosines were identified to give the strongest fluorescence with the formation of G₈-octamers (G₈) both in solution (NMR) and solid state (X-ray). This well-defined G₈-octamer system has provided the first direct evidence on the self-assembled G-quadruplex fluorescence emission with aggregation-induced emission (AIE), which could be applied as the foundation for FL molecular probe design toward G-quadruplex recognition.

SUBMITTER: He Y 

PROVIDER: S-EPMC10723654 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature