The reciprocal regulation between mitochondrial-associated membranes and Notch signaling in skeletal muscle atrophy.

ABSTRACT: Skeletal muscle atrophy and the inhibition of muscle regeneration are known to occur as a natural consequence of aging, yet the underlying mechanisms that lead to these processes in atrophic myofibers remain largely unclear. Our research has revealed that the maintenance of proper mitochondrial-associated endoplasmic reticulum membranes (MAM) is vital for preventing skeletal muscle atrophy in microgravity environments. We discovered that the deletion of the mitochondrial fusion protein Mitofusin2 (MFN2), which serves as a tether for MAM, in human induced pluripotent stem (iPS) cells or the reduction of MAM in differentiated myotubes caused by microgravity interfered with myogenic differentiation process and an increased susceptibility to muscle atrophy, as well as the activation of the Not

SUBMITTER: Ito Y 

PROVIDER: S-EPMC10723794 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature