Mesangial C3 Deposition, Complement-Associated Variant, and Disease Progression in IgA Nephropathy.

ABSTRACT:

Background

IgA nephropathy is the most common primary GN worldwide, with dominant deposition of IgA and co-deposits of complement component 3 (C3). Phenotypes and progression of IgA nephropathy varies among different ethnic populations, while patients with IgA nephropathy from Asia showed more severe clinical phenotypes, active kidney lesions, and rapid progression. Our previous genome-wide association study identified complement factor H ( CFH ) variant rs6677604, tightly linked with the deletion of CFH -related protein 3 and CFH -related protein 1 genes ( ΔCFHR3-1 ), as IgA nephropathy susceptible variant, and additionally revealed its effect on complement regulation in IgA nephropathy.

Methods

To further explore the effect of rs6677604 on IgA nephropathy progression, here

SUBMITTER: Kang Y 

PROVIDER: S-EPMC10723908 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature