Lessons from assembling a microbial natural product and pre-fractionated extract library in an academic laboratory.

ABSTRACT: Microbial natural products are specialized metabolites that are sources of many bioactive compounds including antibiotics, antifungals, antiparasitics, anticancer agents, and probes of biology. The assembly of libraries of producers of natural products has traditionally been the province of the pharmaceutical industry. This sector has gathered significant historical collections of bacteria and fungi to identify new drug leads with outstanding outcomes-upwards of 60% of drug scaffolds originate from such libraries. Despite this success, the repeated rediscovery of known compounds and the resultant diminishing chemical novelty contributed to a pivot from this source of bioactive compounds toward more tractable synthetic compounds in the drug industry. The advent of advanced mass spectrometry

SUBMITTER: Cook MA 

PROVIDER: S-EPMC10724011 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature