Childhood sunburn and risk of melanoma and non-melanoma skin cancer: a Mendelian randomization study.

ABSTRACT: Previous evidence has suggested that childhood sunburn could be a risk factor for cutaneous malignant melanoma (MM) and non-melanoma skin cancer (NMSC). However, existing observational studies could not reveal the causal associations genetically. This study aimed to investigate whether there was a genetic causal relationship between childhood sunburn and skin cancers. Univariable Mendelian randomization (MR) and Causal Analysis Using Summary Effect analysis was carried out for causal estimates and evaluation for the horizontal pleiotropy. Multivariable MR and the mediation effects analysis were used to test whether the causal associations were mediated by potential confounders. A suggestively significant causal association between childhood sunburn and MM was indicated (OR = 4.74; 95% CI:

SUBMITTER: Li Y 

PROVIDER: S-EPMC10724097 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature