A manifold-based framework for studying the dynamics of the vaginal microbiome.

ABSTRACT: The vaginal microbiome plays a crucial role in our health. The composition of this community can be classified into five community state types (CSTs), four of which are primarily consisted of Lactobacillus species and considered healthy, while the fifth features non-Lactobacillus populations and signifies a disease state termed Bacterial vaginosis (BV), which is associated with various symptoms and increased susceptibility to diseases. Importantly, however, the exact mechanisms and dynamics underlying BV development are not yet fully understood, including specifically possible routes from a healthy to a BV state. To address this gap, this study set out to characterize the progression from healthy- to BV-associated compositions by analyzing 8026 vaginal samples and using a manifold-detectio

SUBMITTER: Tsamir-Rimon M 

PROVIDER: S-EPMC10724123 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature