Lipidomic assessment of the impact of Nannochloropsis oceanica microalga lipid extract on human skin keratinocytes exposed to chronic UVB radiation.

ABSTRACT: Considerable attention has been devoted to investigating the biological activity of microalgal extracts, highlighting their capacity to modulate cellular metabolism. This study aimed to assess the impact of Nannochloropsis oceanica lipid extract on the phospholipid profile of human keratinocytes subjected to UVB radiation. The outcomes revealed that treatment of keratinocytes with the lipid extract from microalgae led to a reduction in sphingomyelin (SM) levels, with a more pronounced effect observed in UVB-irradiated cells. Concomitantly, there was a significant upregulation of ceramides CER[NDS] and CER[NS], along with increased sphingomyelinase activity. Pathway analysis further confirmed that SM metabolism was the most significantly affected pathway in both non-irradiated and UVB-irrad

SUBMITTER: Luczaj W 

PROVIDER: S-EPMC10724133 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature