Oxygen supplementation in anesthesia can block FLASH effect and anti-tumor immunity in conventional proton therapy.

ABSTRACT:

Background

Radiation-induced neurocognitive dysfunction is a major adverse effect of brain radiation therapy and has specific relevance in pediatric oncology, where serious cognitive deficits have been reported in survivors of pediatric brain tumors. Moreover, many pediatric patients receive proton therapy under general anesthesia or sedation to guarantee precise ballistics with a high oxygen content for safety. The present study addresses the relevant question of the potential effect of supplemental oxygen administered during anesthesia on normal tissue toxicity and investigates the anti-tumor immune response generated following conventional and FLASH proton therapy.

Methods

Rats (Fischer 344) were cranially irradiated with a single high dose of proton therapy (15 Gy or 25 

SUBMITTER: Iturri L 

PROVIDER: S-EPMC10724215 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature