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Mapping protein states and interactions across the tree of life with co-fractionation mass spectrometry.

ABSTRACT: We present CFdb, a harmonized resource of interaction proteomics data from 411 co-fractionation mass spectrometry (CF-MS) datasets spanning 21,703 fractions. Meta-analysis of this resource charts protein abundance, phosphorylation, and interactions throughout the tree of life, including a reference map of the human interactome. We show how large-scale CF-MS data can enhance analyses of individual CF-MS datasets, and exemplify this strategy by mapping the honey bee interactome.

SUBMITTER: Skinnider MA

PROVIDER: S-EPMC10724252 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Mapping protein states and interactions across the tree of life with co-fractionation mass spectrometry.

Skinnider Michael A MA Akinlaja Mopelola O MO Foster Leonard J LJ

Nature communications 20231215 1

We present CFdb, a harmonized resource of interaction proteomics data from 411 co-fractionation mass spectrometry (CF-MS) datasets spanning 21,703 fractions. Meta-analysis of this resource charts protein abundance, phosphorylation, and interactions throughout the tree of life, including a reference map of the human interactome. We show how large-scale CF-MS data can enhance analyses of individual CF-MS datasets, and exemplify this strategy by mapping the honey bee interactome. ...[more]

PMID: 38102123

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