Peripheral monocytes and neutrophils promote photoreceptor cell death in an experimental retinal detachment model.

ABSTRACT: Photoreceptor cell death and immune cell infiltration are two major events that contribute to retinal degeneration. However, the relationship between these two events has not been well delineated, primarily because of an inadequate understanding of the immunological processes involved in photoreceptor degeneration, especially that of peripheral leukocytes that infiltrate the subretinal space and retinal tissues. In this work, we characterized the role of leukocyte infiltration within the detached retina. We observed that CD45⁺ CD11b⁺ Ly6G⁺ neutrophils and CD45⁺ CD11b⁺ Ly6G^- Ly6C⁺ monocytes are the predominant peripheral immune cell populations that infiltrate the retinal and subretinal space after detachment. Sele

SUBMITTER: Maidana DE 

PROVIDER: S-EPMC10724298 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature