Neutrophil and NETosis Modulation in Traumatic Heterotopic Ossification.

ABSTRACT:

Objective

To characterize the role of neutrophil extracellular traps (NETs) in heterotopic ossification (HO) formation and progression and to use mechanical and pharmacological methods to decrease NETosis and mitigate HO formation.

Background

Traumatic HO is the aberrant osteochondral differentiation of mesenchymal progenitor cells after traumatic injury, burns, or surgery. While the innate immune response has been shown to be necessary for HO formation, the specific immune cell phenotype and function remain unknown. Neutrophils, one of the earliest immune cells to respond after HO-inducing injuries, can extrude DNA, forming highly inflammatory NETs. We hypothesized that neutrophils and NETs would be diagnostic biomarkers and therapeutic targets for the detection and mitigat

SUBMITTER: Nunez JH 

PROVIDER: S-EPMC10724380 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature