Identification and Characterization of CD8⁺ CD27⁺ CXCR3^- T Cell Dysregulation and Progression-Associated Biomarkers in Systemic Lupus Erythematosus.

ABSTRACT: Systemic Lupus Erythematosus (SLE) etiopathogenesis highlights the contributions of overproduction of CD4⁺ T cells and loss of immune tolerance. However, the involvement of CD8⁺ T cells in SLE pathology and disease progression remains unclear. Here, the comprehensive immune cell dysregulation in total 263 clinical peripheral blood samples composed of active SLE (aSLE), remission SLE (rSLE) and healthy controls (HCs) is investigated via mass cytometry, flow cytometry and single-cell RNA sequencing. This is observed that CD8⁺ CD27⁺ CXCR3^- T cells are increased in rSLE compare to aSLE. Meanwhile, the effector function of CD8⁺ CD27⁺ CXCR3^- T cells are overactive in aSLE compare to HCs and rSLE, and are posi

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10724430 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature