Diversity-Oriented Catalytic Asymmetric Dearomatization of Indoles with o-Quinone Diimides.

ABSTRACT: Herein, the first diversity-oriented catalytic asymmetric dearomatization of indoles with o-quinone diimides (o-QDIs) is reported. The catalytic asymmetric dearomatization (CADA) of indoles is one of the research focuses in terms of the structural and biological importance of dearomatized indole derivatives. Although great achievements have been made in target-oriented CADA reactions, diversity-oriented CADA reactions are regarded as more challenging and remain elusive due to the lack of synthons featuring multiple reaction sites and the difficulty in precise control of chemo-, regio-, and enantio-selectivity. In this work, o-QDIs are employed as a versatile building block, enabling the chemo-divergent dearomative arylation and [4 + 2] cycloaddition reactions of indoles. Under the catalysi

SUBMITTER: Gao HJ 

PROVIDER: S-EPMC10724437 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature