Genome-wide identification of transcriptional enhancers during human placental development and association with function, differentiation, and disease†.

ABSTRACT: The placenta is a dynamic organ that must perform a remarkable variety of functions during its relatively short existence in order to support a developing fetus. These functions include nutrient delivery, gas exchange, waste removal, hormone production, and immune barrier protection. Proper placenta development and function are critical for healthy pregnancy outcomes, but the underlying genomic regulatory events that control this process remain largely unknown. We hypothesized that mapping sites of transcriptional enhancer activity and associated changes in gene expression across gestation in human placenta tissue would identify genomic loci and predicted transcription factor activity related to critical placenta functions. We used a suite of genomic assays [i.e., RNA-sequencing (RNA-seq),

SUBMITTER: Owen DM 

PROVIDER: S-EPMC10724456 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature