Notoginsenoside-R1 ameliorates palmitic acid-induced insulin resistance and oxidative stress in HUVEC via Nrf2/ARE pathway.

ABSTRACT: Panax notoginseng, a Chinese traditional food and herb medicine, possesses notable cardiovascular health-promoting properties, with notoginsenoside (NG)-R1 being a key active compound. Insulin resistance represents a global health concern associated with various metabolic disorders. This study investigated the effects of NG-R1 on palmitic acid (PA)-induced insulin resistance and oxidative stress in human umbilical vein endothelial cells (HUVECs). Our findings demonstrate that NG-R1 significantly alleviated impaired glucose uptake, enhanced the phosphorylation of protein kinase B (PKB/Akt) at Ser473, and reduced the phosphorylation of insulin receptor substrate 1 (IRS-1) at Ser307 in PA-treated HUVECs. Furthermore, NG-R1 treatment significantly lowered the levels of malondialdehyde (

SUBMITTER: Wang J 

PROVIDER: S-EPMC10724591 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature