Short-term consumption of highly processed diets varying in macronutrient content impair the sense of smell and brain metabolism in mice.

ABSTRACT:

Objective

Food processing greatly contributed to increased food safety, diversity, and accessibility. However, the prevalence of highly palatable and highly processed food in our modern diet has exacerbated obesity rates and contributed to a global health crisis. While accumulating evidence suggests that chronic consumption of such foods is detrimental to sensory and neural physiology, it is unclear whether its short-term intake has adverse effects. Here, we assessed how short-term consumption (<2 months) of three diets varying in composition and macronutrient content influence olfaction and brain metabolism in mice.

Methods

The diets tested included a grain-based standard chow diet (CHOW; 54% carbohydrate, 32% protein, 14% fat; #8604 Teklad Rodent diet , Envigo Inc.), a hig

SUBMITTER: Makhlouf M 

PROVIDER: S-EPMC10724696 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature