Statin Use and the Risk of Venous Thromboembolism in Women Taking Hormone Therapy.

ABSTRACT:

Importance

Although hormone therapy (HT) in perimenopausal women is associated with increased risk for venous thromboembolism (VTE), it is unclear to what extent statins may mitigate this HT-associated risk.

Objective

To estimate VTE risk in women aged 50 to 64 years taking HT with or without statins.

Design, setting, and participants

This nested case-control study analyzed data from a commercially insured claims database in the US. Eligible participants included women aged 50 to 64 years with at least 1 year of continuous enrollment between 2008 and 2019. Data analysis occurred from January 2022 to August 2023.

Exposure

Filled prescriptions for estrogens, progestogens, and statins were recorded in the 12 months prior to index. Recent HT was defined as any estr

SUBMITTER: Davis JW 

PROVIDER: S-EPMC10724767 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature