Longitudinal hippocampal subfields, CSF biomarkers, and cognition in patients with Parkinson disease.

ABSTRACT:

Objective

Hippocampal atrophy is an indicator of emerging dementia in PD, though it is unclear whether cerebral spinal fluid (CSF) Abeta-42, t-tau, or alpha-syn predict hippocampal subfield atrophy in a de novo cohort of PD patients. To examine whether levels of CSF alpha-synuclein (alpha-syn), beta-amyloid 1-42 (Abeta-42)_, or total-tau (t-tau) are associated with hippocampal subfield volumes over time.

Methods

We identified a subset of Parkinson's Progression Markers Initiative (PPMI) de novo PD patients with longitudinal T1-weighted imaging (baseline plus at least two additional visits across 12, 24, and 48 months) and CSF biomarkers available at baseline. We performed cross-sectional, regression, and linear mixed model analyses to evaluate the bas

SUBMITTER: Erhardt E 

PROVIDER: S-EPMC10724830 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature