Influence of pharmacogenetics on the diversity of response to statins associated with adverse drug reactions.

ABSTRACT:

Background

Statins are one of the most prescribed medications in developed countries as the treatment of choice for reducing cholesterol and preventing cardiovascular diseases. However, a large proportion of patients experience adverse drug reactions, especially myotoxicity. Among the factors that influence the diversity of response, pharmacogenetics emerges as a relevant factor of influence in inter-individual differences in response to statins and can be useful in the prevention of adverse drug effects.

Content

A systematic review was performed of current knowledge of the influence of pharmacogenetics on the occurrence and prevention of statin-associated adverse reactions and clinical benefits of preemptive pharmacogenetics testing.

Summary

Genetic variants SLCO1

SUBMITTER: Sainz de Medrano Sainz JI 

PROVIDER: S-EPMC10724874 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature