A systematic review of simulation studies which compare existing statistical methods to account for non-compliance in randomised controlled trials.

ABSTRACT:

Introduction

Non-compliance is a common challenge for researchers and may reduce the power of an intention-to-treat analysis. Whilst a per protocol approach attempts to deal with this issue, it can result in biased estimates. Several methods to resolve this issue have been identified in previous reviews, but there is limited evidence supporting their use. This review aimed to identify simulation studies which compare such methods, assess the extent to which certain methods have been investigated and determine their performance under various scenarios.

Methods

A systematic search of several electronic databases including MEDLINE and Scopus was carried out from conception to 30th November 2022. Included papers were published in a peer-reviewed journal, readily available in the

SUBMITTER: Abell L 

PROVIDER: S-EPMC10724933 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature