The neural substrates of transdiagnostic cognitive-linguistic heterogeneity in primary progressive aphasia.

ABSTRACT:

Background

Clinical variants of primary progressive aphasia (PPA) are diagnosed based on characteristic patterns of language deficits, supported by corresponding neural changes on brain imaging. However, there is (i) considerable phenotypic variability within and between each diagnostic category with partially overlapping profiles of language performance between variants and (ii) accompanying non-linguistic cognitive impairments that may be independent of aphasia magnitude and disease severity. The neurobiological basis of this cognitive-linguistic heterogeneity remains unclear. Understanding the relationship between these variables would improve PPA clinical/research characterisation and strengthen clinical trial and symptomatic treatment design. We address these knowledge gaps us

SUBMITTER: Ramanan S 

PROVIDER: S-EPMC10724982 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature