Altered expression of inflammation-associated molecules in striatum: an implication for sensitivity to heavy ion radiations.

ABSTRACT:

Background and objective

Heavy ion radiation is one of the major hazards astronauts face during space expeditions, adversely affecting the central nervous system. Radiation causes severe damage to sensitive brain regions, especially the striatum, resulting in cognitive impairment and other physiological issues in astronauts. However, the intensity of brain damage and associated underlying molecular pathological mechanisms mediated by heavy ion radiation are still unknown. The present study is aimed to identify the damaging effect of heavy ion radiation on the striatum and associated underlying pathological mechanisms.

Materials and methods

Two parallel cohorts of rats were exposed to radiation in multiple doses and times. Cohort I was exposed to 15 Gy of ¹²C⁶

SUBMITTER: Chen Z 

PROVIDER: S-EPMC10725200 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature