Inhalation-modulated detection of olfactory BOLD responses in the human brain.

ABSTRACT:

Introduction

In contrast to other sensory domains, detection of primary olfactory processes using functional magnetic resonance imaging has proven to be notably challenging with conventional block designs. This difficulty arises from significant habituation and hemodynamic responses in olfactory areas that do not appear to align with extended boxcar functions convolved with a generic hemodynamic response model. Consequently, some researchers have advocated for a transition to event-related designs, despite their known lower detection power compared to block designs.

Methods

Here, we conducted a block design experiment with 16s of continuous odorant stimulation alternating with 16s of continuous odorless air stimulation in 33 healthy participants. We compared four statistical

SUBMITTER: Alahaivala AI 

PROVIDER: S-EPMC10725246 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature