Sex Differences in the Allele Distribution of PGLYRP2 Variant rs892145 in Parkinson's Disease.

ABSTRACT:

Introduction

Parkinson's disease (PD) is a complex multifactorial disease, involving genetic susceptibility, environmental risk factors, and gene-environmental interactions. The microbiota-gut-brain axis is hypothesized to play a role in the pathophysiology of PD, and peptidoglycan recognition proteins (PGLYRPs), which modulate the gut microbiota, are, therefore, relevant candidate genes for PD.

Methods

Using quantitative real-time PCR, we genotyped three PGLYRP variants (rs892145, rs959117, and rs10888557) and performed an association analysis in 508 PD patients and 585 control individuals. We further conducted a meta-analysis of rs892145 and analyzed PGLYRP2 gene expression in lymphocytes from patients with PD and controls.

Results

Although initial ana

SUBMITTER: Ran C 

PROVIDER: S-EPMC10725317 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature