SNP array genomic analysis of matched pairs of brain and liver metastases in primary colorectal cancer.

ABSTRACT:

Purpose

Brain metastasis formation is a rare and late event in colorectal cancer (CRC) patients and associated with poor survival. In contrast to other metastatic sites, the knowledge on chromosomal aberrations in brain metastases is very limited.

Methods

Therefore, we carried out single nucleotide polymorphism (SNP) array analyses on matched primary CRC and brain metastases of four patients as well as on liver metastases of three patients.

Results

Brain metastases showed more chromosomal aberrations than primary tumors or liver metastases. Commonly occurring aberrations were gain of 8q11.1-q24.3 (primary CRC), gain of 13q12.13-q12.3 (liver metastases), and gain of 20q11.1-q13.33 (brain metastases). Furthermore, we found one copy-neutral loss of heterozygosity (cn-LOH

SUBMITTER: Brandt VP 

PROVIDER: S-EPMC10725338 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature