Characteristics of HPV integration in cervical adenocarcinoma and squamous carcinoma.

ABSTRACT:

Purpose

HPV integration usually occurs in HPV-related cancer, and is the main cause of cancer. But the carcinogenic mechanism of HPV integration is unclear. The study aims to provide a theoretical basis for understanding the pathogenesis of cervical adenocarcinoma (AC) and cervical squamous carcinoma (SCC).

Methods

We used HPV capture sequencing to obtain HPV integration sites in AC and SCC, and analyzed cytobands, distribution of genetic and genomic elements, identified integration hotspot genes, clinicopathological parameters, breakpoints of HPV16 and performed pathway analysis. Then we conducted immunohistochemical (IHC) assay to preliminarily verify the expression of most frequently integrated genes in AC, STARD3 and ERBB2.

Results

The results revealed that the mo

SUBMITTER: Bi Y 

PROVIDER: S-EPMC10725361 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature