The Bacterial G_q Signal Transduction Inhibitor FR900359 Impairs Soil-Associated Nematodes.

ABSTRACT: The cyclic depsipeptide FR900359 (FR) is derived from the soil bacterium Chromobacterium vaccinii and known to bind G_q proteins of mammals and insects, thereby abolishing the signal transduction of their G_q protein-coupled receptors, a process that leads to severe physiological consequences. Due to their highly conserved structure, G_q family of proteins are a superior ecological target for FR producing organisms, resulting in a defense towards a broad range of harmful organisms. Here, we focus on the question whether bacteria like C. vaccinii are important factors in soil in that their secondary metabolites impair, e.g., plant harming organisms like nematodes. We prove that the G_q inhibitor FR is produced under soil-like conditions. Furthermore,

SUBMITTER: Hanke W 

PROVIDER: S-EPMC10725363 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature