Jagged1 contained in MSC-derived small extracellular vesicles promotes squamous differentiation of cervical cancer by activating NOTCH pathway.

ABSTRACT:

Purpose

Cervical cancer is the fourth most common cancer in women and poses a major threat to women's health, urgently requiring new treatment methods.

Methods

This study first successfully extracted and identified small extracellular vesicles secreted by human umbilical cord-derived mesenchymal stem cells. We studied the effects of MSC-sEV on the squamous differentiation levels of cervical cancer CaSki cells in vitro, and explored the effects of MSC-sEV on the NOTCH pathway, the growth, proliferation, migration abilities and squamous differentiation levels of cervical cancer cells. The roles of MSC-sEV were also verified in human keratinocyte HaCaT cells.

Results

The results showed that Jagged1 protein on MSC-sEV can bind to NOTCH1 on cervical cancer cells, activate

SUBMITTER: Li W 

PROVIDER: S-EPMC10725371 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature