Mortality due to non-AIDS-defining cancers among people living with HIV in Spain over 18 years of follow-up.

ABSTRACT:

Purpose

Our aim was to describe non-AIDS-defining cancer (NADC) mortality among people living with HIV (PLWH), to compare it with that of the general population, and to assess potential risk factors.

Methods

We included antiretroviral-naive PLWH from the multicentre CoRIS cohort (2004-2021). We estimated mortality rates and standardised mortality ratios (SMRs). We used cause-specific Cox models to identify risk factors.

Results

Among 17,978 PLWH, NADC caused 21% of all deaths observed during the follow-up. Mortality rate due to NADC was 1.58 (95%CI 1.36, 1.83) × 1000 person-years and lung and liver were the most frequent cancer-related causes of death. PLWH had 79% excess NADC mortality risk compared to the general population with the highest SMR found for Hodgkin lym

SUBMITTER: Suarez-Garcia I 

PROVIDER: S-EPMC10725373 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature