Angiotensin II treatment is associated with improved oxygenation in ARDS patients with refractory vasodilatory shock.

ABSTRACT:

Background

The physiological effects of renin-angiotensin system modulation in acute respiratory distress syndrome (ARDS) remain controversial and have not been investigated in randomized trials. We sought to determine whether angiotensin-II treatment is associated with improved oxygenation in shock-associated ARDS.

Methods

Post-hoc subgroup analysis of the Angiotensin Therapy for High Output Shock (ATHOS-3) trial. We studied patients who met modified Berlin ARDS criteria at enrollment. The primary outcome was PaO₂/FiO₂-ratio (P:F) at 48-h adjusted for baseline P:F. Secondary outcomes included oxygenation index, ventilatory ratio, PEEP, minute-ventilation, hemodynamic measures, patients alive and ventilator-free by day-7, and mortality.

Results

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SUBMITTER: Leisman DE 

PROVIDER: S-EPMC10725390 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature