The role of radiotherapy in the management of malignant peripheral nerve sheath tumors: a single-center retrospective cohort study.

ABSTRACT:

Purpose

This study sought to investigate the role of radiotherapy (RT) in addition to surgery for oncological outcomes in patients with malignant peripheral nerve sheath tumors (MPNST).

Methods

In this single-center, retrospective cohort study, histopathologically confirmed MPNST were analyzed. Local control (LC), overall survival (OS), and distant metastasis-free survival (DMFS) were assessed using the Kaplan-Meier estimator. Multivariable Cox regression analysis was performed to identify factors associated with LC, OS, and DMFS.

Results

We included 57 patients with a median follow-up of 20.0 months. Most MPNSTs were located deeply (87.5%), were larger than 5 cm (55.8%), and had high-grade histology (78.7%). Seventeen patients received surgery only, and 25 patients r

SUBMITTER: Roohani S 

PROVIDER: S-EPMC10725397 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature