Unveiling the molecular basis of lobeline's allosteric regulation of NMDAR: insights from molecular modeling.

ABSTRACT: Neurological and psychiatric disorders contribute significantly to the global disease burden, adversely affecting the quality of life for both patients and their families. Impaired glutamatergic signaling is considered to be a major cause for most of the neurological and psychiatric disorders. Glutamate receptors are over activated in excitotoxic conditions, leading to dysregulation of Ca²⁺ homeostasis, triggering the production of free radicals and oxidative stress, mitochondrial dysfunction and eventually cell death. Excitotoxicity primarily results from the overactivity of NMDARs, a subtype of ionotropic glutamate receptors, due to their pronounced Ca²⁺ permeability and conductance characteristics. NMDAR antagonists are suggested to have therapeutic use as they can

SUBMITTER: Remya C 

PROVIDER: S-EPMC10725453 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature