Transcriptional signatures of the whole-brain voxel-wise resting-state functional network centrality alterations in schizophrenia.

ABSTRACT: Neuroimaging studies have revealed that patients with schizophrenia exhibit disrupted resting-state functional connectivity. However, the inconsistent findings across these studies have hindered our comprehensive understanding of the functional connectivity changes associated with schizophrenia, and the molecular mechanisms associated with these alterations remain largely unclear. A quantitative meta-analysis was first conducted on 21 datasets, involving 1057 patients and 1186 healthy controls, to examine disrupted resting-state functional connectivity in schizophrenia, as measured by whole-brain voxel-wise functional network centrality (FNC). Subsequently, partial least squares regression analysis was employed to investigate the relationship between FNC changes and gene expression profile

SUBMITTER: Guo L 

PROVIDER: S-EPMC10725456 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature