Identification and validation of a seven cuproptosis-associated lncRNA signature to predict the prognosis of endometrial cancer.

ABSTRACT:

Objective

Endometrial cancer (EC) is one of the most prevalent cancers in women. Long non-coding RNAs (lncRNAs) are potential diagnostic biomarkers in patients with EC.

Methods

We obtained clinical information and transcriptome data for 552 patients with EC from The Cancer Genome Atlas database. Cuproptosis-associated lncRNAs were obtained through Pearson's correlation analysis. Univariate and multivariate Cox regression analyses were applied and a signature predicting overall survival (OS) among patients with EC was constructed. We also analyzed the tumor immune microenvironment and drug sensitivity. The results were validated by quantitative real time-polymerase chain reaction, and 5-ethynyl-2'-deoxyuridine and wound-healing assays.

Results

Seven cuproptosis-associa

SUBMITTER: Cai L 

PROVIDER: S-EPMC10725657 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature