Kinetic modelling of β-cell metabolism reveals control points in the insulin-regulating pyruvate cycling pathways.

ABSTRACT: Insulin, a key hormone in the regulation of glucose homoeostasis, is secreted by pancreatic β-cells in response to elevated glucose levels. Insulin is released in a biphasic manner in response to glucose metabolism in β-cells. The first phase of insulin secretion is triggered by an increase in the ATP:ADP ratio; the second phase occurs in response to both a rise in ATP:ADP and other key metabolic signals, including a rise in the NADPH:NADP⁺ ratio. Experimental evidence indicates that pyruvate-cycling pathways play an important role in the elevation of the NADPH:NADP⁺ ratio in response to glucose. The authors developed a kinetic model for the tricarboxylic acid cycle and pyruvate cycling pathways. The authors successfully validated the model against experimental observ

SUBMITTER: Rahul R 

PROVIDER: S-EPMC10725709 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature