Predictors of Osteonecrosis in Systemic Lupus Erythematosus: A Prospective Cohort Study.

ABSTRACT:

Objective

We aimed at determining the predictors of osteonecrosis (ON) in a longitudinal lupus cohort.

Methods

Data were reviewed from the initiation of the cohort in 1987 until October 2019. In total, 2,428 patients were included in the analysis based on 224,295 person-months of follow-up. We used pooled logistic regression to assess the relationship between risk factors and rates of ON events. After identifying a set of variables related to ON incidence, we fit a final multivariable model to identify the most important risk factors for incident ON.

Results

In 18,691 person-years of follow-up after cohort entry, 122 incident ON events were observed (rate = 6.5/1,000 person-years). In the multivariable analysis, African American patients were at twice the risk for ON

SUBMITTER: Kallas R 

PROVIDER: S-EPMC10725725 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature