Neonatal nephrotoxic medication exposure and early acute kidney injury: results from the AWAKEN study.

ABSTRACT:

Background

We aimed to describe nephrotoxic medication exposure and investigate associations between exposure and acute kidney injury (AKI) in the neonatal intensive care unit during the first postnatal week.

Design/methods

Secondary analysis of the AWAKEN cohort. We evaluated nephrotoxic medication exposure during the first postnatal week and associations with AKI using time-varying Cox proportional hazard regressions models. Nephrotoxic medication exposure categories were defined as: no nephrotoxic medication, nephrotoxic medications excluding aminoglycosides, aminoglycoside alone, and aminoglycoside and another nephrotoxic medication.

Results

Of 2162 neonates, 1616 (74.7%) received ≥1 nephrotoxic medication. Aminoglycoside receipt was most common (72%). AKI develop

SUBMITTER: Steflik HJ 

PROVIDER: S-EPMC10725773 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature