Gene-environment interaction study on the polygenic risk score for neuroticism, childhood adversity, and parental bonding.

ABSTRACT: The present study examines whether neuroticism is predicted by genetic vulnerability, summarized as polygenic risk score for neuroticism (PRS_N), in interaction with bullying, parental bonding, and childhood adversity. Data were derived from a general population adolescent and young adult twin cohort. The final sample consisted of 202 monozygotic and 436 dizygotic twins and 319 twin pairs. The Short Eysenck Personality questionnaire was used to measure neuroticism. PRS_N was trained on the results from the Genetics of Personality Consortium (GPC) and United Kingdom Biobank (UKB) cohorts, yielding two different PRS_N. Multilevel mixed-effects models were used to analyze the main and interacting associations of PRS_N, childh

SUBMITTER: Klingenberg B 

PROVIDER: S-EPMC10725776 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature