Phenotypic shifts induced by environmental pre-stressors modify antibiotic resistance in Staphylococcus aureus.

ABSTRACT:

Introduction

Escalating prevalence of antibiotic resistance in Staphylococcus aureus has necessitated urgent exploration into the fundamental mechanisms underlying antibiotic resistance emergence, particularly in relation to its interaction with environmental stressors. This study aimed to investigate the effects of environmental stressors prior to antibiotic exposure on the antibiotic resistance of S. aureus.

Methods

We used Raman spectroscopy and flow cytometry to measure prior stress-induced phenotypic alterations of S. aureus, and identified the association between phenotypic shifts and the antibiotic resistance.

Results

The results revealed a multifaceted relationship between stressors and the development of antibiotic resistance. The stresso

SUBMITTER: Wee GN 

PROVIDER: S-EPMC10725907 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature