The involvement of brain regions associated with lower KPS and shorter survival time predicts a poor prognosis in glioma.

ABSTRACT:

Background

Isocitrate dehydrogenase-wildtype glioblastoma (IDH-wildtype GBM) and IDH-mutant astrocytoma have distinct biological behaviors and clinical outcomes. The location of brain tumors is closely associated not only with clinical symptoms and prognosis but also with key molecular alterations such as IDH. Therefore, we hypothesize that the key brain regions influencing the prognosis of glioblastoma and astrocytoma are likely to differ. This study aims to (1) identify specific regions that are associated with the Karnofsky Performance Scale (KPS) or overall survival (OS) in IDH-wildtype GBM and IDH-mutant astrocytoma and (2) test whether the involvement of these regions could act as a prognostic indicator.

Methods

A total of 111 patients with IDH-wildtype GBM and 78 pati

SUBMITTER: Bao H 

PROVIDER: S-EPMC10725945 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature