PD-L1 expression complements CALGB prognostic scoring system in malignant pleural mesothelioma.

ABSTRACT:

Background

Programmed death ligand-1 (PD-L1) expression is a predictive biomarker in patients with lung cancer, but its role in malignant pleural mesothelioma (MPM) remains unclear. Evidence suggests that higher PD-L1 expression is correlated with worse survival. CALGB is the main scoring system used to predict the benefit of chemotherapy treatment. This study aimed to determine the prognostic value of PD-L1 expression and its addition to CALGB scoring system in patients with MPM.

Methods

In this retrospective analysis, we evaluated samples with confirmed locally advanced or metastatic MPM. PD-L1 Tumor Proportional Score (TPS) was determined by immunohistochemistry at diagnosis.

Results

73 patients were included in this study. A cutoff value of 15 was set for a high o

SUBMITTER: Aviles-Salas A 

PROVIDER: S-EPMC10725960 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature