The selective inhibition of the Syk tyrosine kinase ameliorates experimental autoimmune arthritis.

ABSTRACT: Autoimmune arthritis - such as rheumatoid arthritis - affect a significant proportion of the population, which can cause everyday joint pain, decreased mobility and reduced quality of life. Despite having more and more therapeutic options available, there are still a lot of patients who cannot reach remission or low disease activity by current therapies. This causes an urgent need for the development of new treatment options. The Syk tyrosine kinase plays an essential role in B cell receptor, Fc receptor and integrin signaling. It has been shown that the hematopoietic cell-specific deletion of Syk resulted in a complete protection against autoantibody-induced experimental arthritis. This prompted us to test the effect of entospletinib, a second generation, Syk-selective inhibitor, which ha

SUBMITTER: Kaposztas E 

PROVIDER: S-EPMC10725968 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature