Serum proteomic panel validated for prediction of knee osteoarthritis progression.

ABSTRACT:

Objective

To further validate a serum proteomics panel for predicting radiographic (structural) knee OA progression.

Design

Serum peptides were targeted by multiple-reaction-monitoring mass spectrometry in the New York University cohort (n ​= ​104). Knee OA progression was defined as joint space narrowing ≥1 in the tibiofemoral compartment of one knee per study participant over a 24-month follow-up. The discriminative ability of an 11-peptide panel was evaluated by multivariable logistic regression and area under the receiver operating characteristic curve (AUC), without and with demographic characteristics of age, sex, and body mass index. The association of each peptide with OA progression was assessed by odds ratios (OR) in multivariable logistic regression models adjuste

SUBMITTER: Kraus VB 

PROVIDER: S-EPMC10726242 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature