Self-Defensive Antimicrobial Shape Memory Polyurethanes with Honey-Based Compounds.

ABSTRACT: Infection treatment plays a crucial role in aiding the body in wound healing. To that end, we developed a library of antimicrobial polymers based on segmented shape memory polyurethanes with nondrug-based antimicrobials (i.e., honey-based phenolic acids (PAs)) using both chemical and physical incorporation approaches. The antimicrobial shape memory polymers (SMPs) have high transition temperatures (>55 °C) to enable maintenance of temporary, programmed shapes in physiological conditions unless a specific external stimulus is present. Polymers showed tunable mechanical and shape memory properties by changing the ratio, chemistry, and incorporation method of PAs. Cytocompatible (∼100% cell viability) synthesized polymers inhibited growth rates of Staphylococcus aureus (∼100% with phys

SUBMITTER: Ramezani M 

PROVIDER: S-EPMC10726308 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature