Epigenomic mapping reveals distinct B cell acute lymphoblastic leukemia chromatin architectures and regulators.

ABSTRACT: B cell lineage acute lymphoblastic leukemia (B-ALL) is composed of diverse molecular subtypes, and while transcriptional and DNA methylation profiling has been extensively examined, the chromatin landscape is not well characterized for many subtypes. We therefore mapped chromatin accessibility using ATAC-seq in primary B-ALL cells from 156 patients spanning ten molecular subtypes and present this dataset as a resource. Differential chromatin accessibility and transcription factor (TF) footprint profiling were employed and identified B-ALL cell of origin, TF-target gene interactions enriched in B-ALL, and key TFs associated with accessible chromatin sites preferentially active in B-ALL. We further identified over 20% of accessible chromatin sites exhibiting strong subtype enrichment and can

SUBMITTER: Barnett KR 

PROVIDER: S-EPMC10726428 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature