New Teixobactin Analogues with a Total Lactam Ring.

ABSTRACT: Teixobactin is a new antibiotic peptide with strong efficacy against several Gram-positive resistant bacteria, the structure of which is extremely difficult to obtain in the laboratory via multistep conventional synthesis. To face the increasing antibiotic resistant bacteria, it is fundamental to introduce new types of antibiotics with innovative mechanisms of action without resistance; thus, many scientists are studying and developing new methods to synthesize teixobactin analogues. In this work, seven Arg₁₀-teixobactin analogues with a total lactam ring have been prepared via solid phase peptide synthesis. In order to obtain the total lactam ring, d-Thr₈ was replaced by (2R,3S)-diamino-propionic acid. To verify their antimicrobial activity and efficacy

SUBMITTER: Scioli G 

PROVIDER: S-EPMC10726481 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature