Tuftelin1 drives experimental pulmonary fibrosis progression by facilitating stress fiber assembly.

ABSTRACT:

Background

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease (ILD) with unknown etiology, characterized by sustained damage repair of epithelial cells and abnormal activation of fibroblasts, the underlying mechanism of the disease remains elusive.

Methods

To evaluate the role of Tuftelin1 (TUFT1) in IPF and elucidate its molecular mechanism. We investigated the level of TUFT1 in the IPF and bleomycin-induced mouse models and explored the influence of TUFT1 deficiency on pulmonary fibrosis. Additionally, we explored the effect of TUFT1 on the cytoskeleton and illustrated the relationship between stress fiber and pulmonary fibrosis.

Results

Our results demonstrated a significant upregulation of TUFT1 in IPF and the bleomycin (BLM)-induced fi

SUBMITTER: Niu C 

PROVIDER: S-EPMC10726504 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature