Sex and interspecies differences in ESR2-expressing cell distributions in mouse and rat brains.

ABSTRACT:

Background

ESR2, a nuclear estrogen receptor also known as estrogen receptor β, is expressed in the brain and contributes to the actions of estrogen in various physiological phenomena. However, its expression profiles in the brain have long been debated because of difficulties in detecting ESR2-expressing cells. In the present study, we aimed to determine the distribution of ESR2 in rodent brains, as well as its sex and interspecies differences, using immunohistochemical detection with a well-validated anti-ESR2 antibody (PPZ0506).

Methods

To determine the expression profiles of ESR2 protein in rodent brains, whole brain sections from mice and rats of both sexes were subjected to immunostaining for ESR2. In addition, to evaluate the effects of circulating estrogen on ESR2 ex

SUBMITTER: Morishita M 

PROVIDER: S-EPMC10726529 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature